Transferrin-phosphatidylserine liposomes target TDP-43 and neuroinflammation in male mice with neuropathic pain

 Transferrin-phosphatidylserine liposomes target TDP-43 and neuroinflammation in male mice with neuropathic pain

Neuropathic pain is driven by chronic neuroinflammation involving dysfunction of microglia and astrocytes. Here, the authors develop nanoparticles that block TDP-43 aggregation and suppress glial activation via the cGAS-STING pathway in a mouse model, highlig…

  • Fiore, N. T., Debs, S. R., Hayes, J. P., Duffy, S. S. & Moalem-Taylor, G. Pain-resolving immune mechanisms in neuropathic pain. Nat. Rev. Neurol.https://doi.org/10.1038/s41582-023-00777-3 (20…